Thomas Hunt Morgan Professor of Biology, Emeritus
Edward B. Lewis died on July 21, 2004.
study of genetic mutations in fruit flies and how these affect an insect's development. His pioneering work on homeotic genes induced other scientists to examine families of analogous genes in higher organisms.
In the 1950s, Pr Lewis played a key role in discovering and explaining the role of homeotic genes, genes that influence how the undifferentiated cells in a fertilized embryo separate into a head and a tail end, and how the eyes, legs, antennae, and other organs all form in their correct positions. These genes are highly conserved -that is, they are very similar- in all organisms, and play a role in the development of everything from fruit flies to mice to humans.
Honorary Doctor of Philosophy, University of Umeå, Umeå, Sweden, 1981
Thomas Hunt Morgan Medal of the Genetics Society of America, 1983
Gairdner Foundation International Award (Canada), 1987
Wolf Prize in Medicine (Israel), 1989
Lewis S. Rosenstiel Award in Basic Medical Research, 1990
National Medal of Science (USA), 1990
Honorary Member, The Genetical Society (UK), 1990
Albert Lasker Basic Medical Research Award, 1991
The Louisa Gross Horwitz Prize, 1992
Honorary Doctor of Science, University of Minnesota, 1993
1995 Nobel Prize for "the genetic control of early embryonic development."
Lewis, E. B. The phenomenon of position effect. Advances in Genetics 3: 73-115.
Lewis, E. B. Pseudoallelism and gene evolution. Cold Spring Harbor Symposia on Quantitative Biology 16: 159-174.
Lewis, E. B. Genetic control and regulation of developmental pathways. Role of Chromosomes in Development, pp. 231-252. Edited by M. Locke. Adacemic Press, New York.
Lewis, E. B. Genes and gene complexes. Heritage from Mendel, pp. 17-47. Edited by R. A. Brink. University of Wisconsin Press, Madison, Wisconsin.
Garcia-Bellido, A. and Lewis, E. B. Autonomous cellular differentiation of homoeotic bithorax mutants of Drosophila melanogaster. Develop. Biol. 48: 400-410.
Lewis, E. B. A gene complex controlling segmentation in Drosophila. Nature 276: 565-570.
Duncan, Ian and Lewis, E. B. Genetic control of body segment differentiation in Drosophila. In Developmental Order: Its Origin and Regulation. 40th Annual Symposium of the Society for Developmental Biology, Boulder, Colorado, June 1981. Edited by S. Subtelny and P. B. Green. Alan R. Liss, Inc., New York, 1982, pp. 533-554.
Lewis, E. B. Control of body segment differentiation in Drosophila by the bithorax gene complex. In Embryonic Development, Part A: Genetic Aspects. Edited by M. M. Burger and R. Weber. Alan R. Liss, New York., pp. 269-288.
Bender, W., Akam, M., Karch, F, Beachy, P. A., Peifer, M., Spierer, P., Lewis, E. B. and Hogness, D. S. Molecular genetics of the bithorax complex in Drosophila melanogaster. Science 221: 23-29.
Karch, F, Weiffenbach, B., Peifer, M., Bender, W., Duncan, I., Celniker, S., Crosby, M. and Lewis, E. B. The abdominal region of the bithorax complex. Cell 43: 81-96.
Lewis, E. B. Regulation of the genes of the bithorax complex in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology, 50: 155-164.
Celniker, S. E. and Lewis, E. B. Transabdominal, a dominant mutant of the Bithorax Complex, produces sexually dimorphic segmental transformation of Drosophila. Genes and Development 1: 111-123.
Celniker, S. E., Keelan, D. and Lewis, E. B. The molecular genetics of the Bithorax Complex of Drosophila: Characterization of the products of the Abdominal-B domain. Genes and Development 3: 1424-1435.
Celniker, S. E., Sharma, S., Keelan, D. and Lewis, E. B. The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. EMBO J. 9: 4277-4286.
Lewis, E. B. Clusters of master control genes regulate the development of higher organisms. The 1991 Albert Lasker Medical Awards. JAMA 267:1524-1531.
Celniker, S. E. and Lewis, E. B. Molecular basis of Transabdominal-a novel sexually dimorphic mutant of the bithorax complex of Drosophila. Proc. Natl. Acad. Sci. 90: 1566-1570.
Fernandes, J., Celniker, S. E., Lewis, E. B. and VijayRaghavan, K. Muscle development in the four-winged Drosophila and the role of the Ultrabithorax gene. Current Biology 4: 957-964.
Martin, C. H., Mayeda, C. A., Davis, C. A., Ericsson, C. L., Knafels, J. D., Mathog, D. R., Celniker, S. E., Lewis, E. B. and Palazzolo, M.J. Complete sequence of the bithorax complex of Drosophila. Proc. Natl. Acad. Sci. 92: 8398-8402.
Lewis, E. B., Knafels, J. D., Mathog, D. R. and Celniker, S. E. Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila. Proc. Natl. Acad. Sci. 92: 8403-8407.