With colleagues and students from Nevis he led an extensive and wide-ranging series of experiments that provided major advances in the understanding of particles and interactions, thus contributing significantly to what is known as the "standard model."
Major experiments included the observation of parity violation in decay of pi and mu mesons, the discovery of the long-lived neutral kaon, the discovery of two kinds of neutrinos and the discovery of the upsilon particle, the first evidence for the bottom quark.
National Medal of Science (1965),
Elliot Cresson Medal of the Franklin Institute (1976),
Wolf Prize in Physics (1982),
Nobel Prize in Physics (1988), with Melvin Schwartz and Jack Steinberger, "for the neutrino beam method and the demonstration of the doublet structure of the leptons through the discovery of the muon neutrino."
Enrico Fermi Prize (1993).
From Quarks to the Cosmos: Tools of Discovery (with David Schramm) 1995 W. H. Freeman
The God Particle: If the Universe is the Answer, What is the Question ? (1989, written with Dick Teresi), 1993 Dell/Bantam.