GUINDON, YVAN / Chemistry / Researchers

International Center for Scientific Research

Researchers

Chemistry / GUINDON, YVAN

Yvan.Guindonircm.qc.ca

Position

Chercheur titulaire, Directeur de l\'unité de recherche en chimie bioorganique,Institut de recherches cliniques de Montréal (Québec), Canada.

Research interests

Développement de nouveaux agents thérapeutiques faisant appel à la chimie glycomimétique. Développement de ligands spécifiques aux sélectines, agents potentiellement thérapeutiques pour contrôler l\'inflammation, et/ou les métastases. Synthèse de produits naturels d\'intérêt biologique. Nouveaux réactifs: synthèse et caractérisation de nouveaux réactifs (chimie du bore) d\'intérêt potentiel en chimie organique. Méthodologie de synthèse: conceptualisation et développement de nouvelles approches de synthèse; induction asymétrique; stéréosélection par voies radicalaires. Intérêts de recherche: Influence d\'acides de Lewis sur le contrôle de la diastéréosélectivité pour les réactions de réduction, d\'addition et de cyclisation radicalaire. Synthèses d\'analogues de sialyle Lewis X et de N-nucléosides.

Prizes and awards

Membre de l\'Institut de chimie du Canada (1988)
Membre de la Société royale du Canada, Académie des sciences (1990)
Membre de l\'Ordre du Canada (2004)
Prix Lionel-Boulet (2006)

Publications

\"Phenylselenoethers as Precursors of Acyclic Free Radicals. Creating Tertiary and Quaternary Centers Using Free Radical-Based Intermediates\". B. Cardinal-David, J.-F. Brazeau, I. A. Katsoulis and Y. Guindon; Curr. Org. Chem., 2006, 10, 1939-1961.

\"Synthesis of Tertiary and Quaternary Stereogenic Centers: A Diastereoselective Tandem Reaction Sequence Combining Mukaiyama and Free Radical-Based Allylation\". Y. Guindon, B. Cardinal-David, B. Guérin; J. Org. Chem., 2005, 70, 776-784.

\"Synthesis of Postulated Molecular Probes: Stereoselective Free-Radical-Mediated C-Glycosylation in Tandem with Hydrogen Transfer\". Y. Guindon, M. Bencheqroun, A. Bouzide; J. Am. Chem. Soc., 2005, 127, 554-558.

\"Diastereoselective Mukaiyama and Free Radical Processes for the Synthesis of Polypropionate Units\". Y. Guindon, Jean-François Brazeau; Organic Letters, 2004, 6, 2599-2602.

\"Opening of Tartrate Acetals Using Dialkylboron Bromide: Evidence for Stereoselectivity Downstream from Ring Fission\". Y. Guindon, W.W. Ogilvie, J. Bordeleau, W. Cui, K. Durkin, V. Gorys, H. Juteau, R. Lemieux, D. Liotta ,B. Simoneau, C. Yoakim; J. Am. Chem. Soc., 2003, 125, 428-436.

\"Synthesis of Polypropionate Motifs Containing the Anti-Anti Unit\". P. Mochirian, B. Cardinal-David, B. Guérin, M. Prévost, Y. Guindon; Tetrahedron Lett., 2002, 43, 7067-7071.

\"Synthesis of 2,3-anti -3,4-anti and 2,3-anti -3,4-syn Propionate Motifs: A Diastereoselective Tandem Sequence of Mukaiyama and Free-Radical Based Hydrogen Transfer Reactions\". Y. Guindon, M. Prévost, P. Mochirian, B. Guérin; Organic Letters, 2002, 4, 1019-1022.

\"Synthesis of N-Glycosides. An Alternative Approach Based on Diastereoselective Base Coupling and SN2 Cyclization\". Y. Guindon, M. Gagnon, I. Thumin, D. Chapdelaine, B. Guérin; Organic Letters, 2002, 4, 241-244.

\"Diastereoselective Synthesis of 2,3,5-trisubstituted Tetrahydrofurans via Cyclofunctionalization Reactions. Evidence of Stereoelectronic Effects\". Y. Guindon, F. Soucy, C. Yoakim, W.W. Ogilvie, L. Plamondon; J. Org. Chem., 2001, 66, 8992-8996.

\"Influence of N-substituted Lactams on Acyclic Free Radical Based Hydrogen Transfer\". Y. Guindon, A. Slassi, M. Bencheqroun; Tetrahedron Lett., 2001, 42, 6041-6044.

\"Intramolecular aminyl and iminyl radical additions to ?,?-unsaturated esters. Diastereoselective tandem cyclofunctionalization and hydrogen transfer reactions\". Y. Guindon, B. Guérin, S.R. Landry; Organic Letters, 2001, 3, 2293-2296.

\"Synthesis of Propionate Motifs: Diastereoselective Tandem Reactions Involving Anionic and Free Radical Based Processes\". Y. Guindon, K. Houde, M. Prévost, B. Cardinal-David, S.R. Landry, B. Daoust, M. Bencheqroun, B. Guérin; J. Am. Chem. Soc., 2001, 123, 8496-8501.

\"Design and synthesis of a new Sialyl Lewis X mimetic: How selective are the selectin receptors?\". M. De Vleeschauwer, M. Vaillancourt, N. Goudreau, Y. Guindon, D. Gravel; Bioorganic & Medicinal Chemistry Letters, 2001, 11, 1109-1112.

\"Cyclofunctionalization and Free Radical Based Hydrogen Transfer Reactions. An Iterative Reaction Sequence Applied to the Synthesis of the C7-C16 Subunit of Zincophorin\". Y. Guindon, L. Murtagh, V. Caron, S.R. Landry, G. Jung, M. Bencheqroun, A.-M. Faucher, B. Guérin; J. Org. Chem., 2001, 66, 5427-5437.

\"Stereocontrol in Radical Processes through the Exocyclic Effect: Dual Role of Triethylboron as Radical Initiator and In Situ Derivatization Agent\". J.-P. Bouvier, G. Jung, Z. Liu, B. Guérin, Y. Guindon; Organic Letters, 2001, 3, 1391-1394.

\"Free Radicals and Lewis Acid. Chelation-Controlled Radical Allylations of Substituted ?-Halo- or ?-Phenylseleno-?-Alkoxy Esters. The Endocyclic Effect\". B. Guérin, C. Chabot, N. Mackintosh, W.W. Ogilvie, Y. Guindon; Can. J. Chem., 2000, 78, 852-867.

Legal notice - Contact

Copyright © 2013 - www.cirs.info - All rights reserved