LEWIS, EDWARD B. / Life sciences / Researchers

International Center for Scientific Research

Researchers

Life sciences / LEWIS, EDWARD B.


Position

Thomas Hunt Morgan Professor of Biology, Emeritus

Edward B. Lewis died on July 21, 2004.

Research interests

study of genetic mutations in fruit flies and how these affect an insect's development. His pioneering work on homeotic genes induced other scientists to examine families of analogous genes in higher organisms.

In the 1950s, Pr Lewis played a key role in discovering and explaining the role of homeotic genes, genes that influence how the undifferentiated cells in a fertilized embryo separate into a head and a tail end, and how the eyes, legs, antennae, and other organs all form in their correct positions. These genes are highly conserved -that is, they are very similar- in all organisms, and play a role in the development of everything from fruit flies to mice to humans.

Prizes and awards

Honorary Doctor of Philosophy, University of Umeå, Umeå, Sweden, 1981
Thomas Hunt Morgan Medal of the Genetics Society of America, 1983
Gairdner Foundation International Award (Canada), 1987
Wolf Prize in Medicine (Israel), 1989
Lewis S. Rosenstiel Award in Basic Medical Research, 1990
National Medal of Science (USA), 1990
Honorary Member, The Genetical Society (UK), 1990
Albert Lasker Basic Medical Research Award, 1991
The Louisa Gross Horwitz Prize, 1992
Honorary Doctor of Science, University of Minnesota, 1993
1995 Nobel Prize for "the genetic control of early embryonic development."

Publications

1950
Lewis, E. B. The phenomenon of position effect. Advances in Genetics 3: 73-115.

1951
Lewis, E. B. Pseudoallelism and gene evolution. Cold Spring Harbor Symposia on Quantitative Biology 16: 159-174.

1964
Lewis, E. B. Genetic control and regulation of developmental pathways. Role of Chromosomes in Development, pp. 231-252. Edited by M. Locke. Adacemic Press, New York.

1968
Lewis, E. B. Genes and gene complexes. Heritage from Mendel, pp. 17-47. Edited by R. A. Brink. University of Wisconsin Press, Madison, Wisconsin.

1976
Garcia-Bellido, A. and Lewis, E. B. Autonomous cellular differentiation of homoeotic bithorax mutants of Drosophila melanogaster. Develop. Biol. 48: 400-410.

1978
Lewis, E. B. A gene complex controlling segmentation in Drosophila. Nature 276: 565-570.

1982
Duncan, Ian and Lewis, E. B. Genetic control of body segment differentiation in Drosophila. In Developmental Order: Its Origin and Regulation. 40th Annual Symposium of the Society for Developmental Biology, Boulder, Colorado, June 1981. Edited by S. Subtelny and P. B. Green. Alan R. Liss, Inc., New York, 1982, pp. 533-554.

1982
Lewis, E. B. Control of body segment differentiation in Drosophila by the bithorax gene complex. In Embryonic Development, Part A: Genetic Aspects. Edited by M. M. Burger and R. Weber. Alan R. Liss, New York., pp. 269-288.

1983
Bender, W., Akam, M., Karch, F, Beachy, P. A., Peifer, M., Spierer, P., Lewis, E. B. and Hogness, D. S. Molecular genetics of the bithorax complex in Drosophila melanogaster. Science 221: 23-29.

1985
Karch, F, Weiffenbach, B., Peifer, M., Bender, W., Duncan, I., Celniker, S., Crosby, M. and Lewis, E. B. The abdominal region of the bithorax complex. Cell 43: 81-96.

1986
Lewis, E. B. Regulation of the genes of the bithorax complex in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology, 50: 155-164.

1987
Celniker, S. E. and Lewis, E. B. Transabdominal, a dominant mutant of the Bithorax Complex, produces sexually dimorphic segmental transformation of Drosophila. Genes and Development 1: 111-123.

1989
Celniker, S. E., Keelan, D. and Lewis, E. B. The molecular genetics of the Bithorax Complex of Drosophila: Characterization of the products of the Abdominal-B domain. Genes and Development 3: 1424-1435.

1990
Celniker, S. E., Sharma, S., Keelan, D. and Lewis, E. B. The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. EMBO J. 9: 4277-4286.

1992
Lewis, E. B. Clusters of master control genes regulate the development of higher organisms. The 1991 Albert Lasker Medical Awards. JAMA 267:1524-1531.

1993
Celniker, S. E. and Lewis, E. B. Molecular basis of Transabdominal-a novel sexually dimorphic mutant of the bithorax complex of Drosophila. Proc. Natl. Acad. Sci. 90: 1566-1570.

1994
Fernandes, J., Celniker, S. E., Lewis, E. B. and VijayRaghavan, K. Muscle development in the four-winged Drosophila and the role of the Ultrabithorax gene. Current Biology 4: 957-964.

1995
Martin, C. H., Mayeda, C. A., Davis, C. A., Ericsson, C. L., Knafels, J. D., Mathog, D. R., Celniker, S. E., Lewis, E. B. and Palazzolo, M.J. Complete sequence of the bithorax complex of Drosophila. Proc. Natl. Acad. Sci. 92: 8398-8402.

1995
Lewis, E. B., Knafels, J. D., Mathog, D. R. and Celniker, S. E. Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila. Proc. Natl. Acad. Sci. 92: 8403-8407.

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