Professor in the Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles.
Regulation and modulation of NO production
Ignarro discovered that nitric oxide (NO) relaxes vascular smooth muscle; inhibits platelet aggregation; is a neurotransmitter mediating erectile function; is responsible for the action of nitroglycerin in vascular smooth muscle, where it activates guanylate cyclase by heme-dependent mechanisms; and is identical with endothelium-derived relaxing factor.
1998 Nobel Prize in Medicine for his discovery concerning nitric oxide as a signalling molecule in the cardiovascular system.
No More Heart Disease: How Nitric Oxide Can Prevent--Even Reverse-- Heart Disease And Stroke, 1st Edition
By Louis J. Ignarro
Hardcover / 248 Pages / St Martins Pr / February 2005 / 0312335814
Pharmacology for the Boards and Wards (Illustrated)
By Louis J. Ignarro, Carlos Ayala, Brad Spellberg
Paperback / 220 Pages / Blackwell Pub / August 2002 / 1405103248
Nitric Oxide: Biology and Pathobiology, 1st Edition (Illustrated)
By Louis J. Ignarro (Editor)
Hardcover / 1003 Pages / Academic Pr / August 2000 / 0123704200
Griscavage, J.M., Fukuto, J.M., Komori, Y., Ignarro, L.J. Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.. J. Biol. Chem. 1994; 269: 21644-21649.
Rajfer, J., Aronson, W.J., Bush, P.A., Dorey, F.J. and Ignarro, L.J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission.. N. Engl. J. Med. 1992; 326: 90-94.