MIGNOT, EMMANUEL / علم الطب / الباحثون

المركز الدولي للبحث العلمي

الباحثون

علم الطب / MIGNOT, EMMANUEL

kstoverstanford.edu

الموضع

Howard Hughes Medical Institute Investigator, professor of psychiatry and behavioral sciences and director of the Center for Narcolepsy at Stanford University.

مواضيع البحث

Dr. Mignot is internationally recognized as having discovered the cause of narcolepsy. His laboratory uses a multidisciplinary approach, including epidemiology, genetics and animal models, to study sleep disorders and sleep physiology.

He is also known for his discovery of a polymorphism of the \"clock\" gene that appears to alter individuals\' internal biorhythms and for the finding of a gene variant that predisposes to sleep apnea.

الجوائز

Dr. Mignot has received numerous research grants and honors, including National Sleep Foundation and National Institute of Health Research Awards, the Narcolepsy Network professional service award, the Drs. C. and F. Demuth 11th Award for Young Investigators in the Neurosciences, the WC Dement Academic Achievement Award in sleep disorders medicine, the CINP and ACNP awards in neuropharmacology and the Jacobaeus prize.

المنشورات

Mignot E, Lin L, Finn L, Lopes C, Pluff K, Sundstrom ML, Young T \"Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults.\" Brain 2006

Zeitzer JM, Nishino S, Mignot E \"The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions.\" Trends Pharmacol Sci 2006

Crocker A, España RA, Papadopoulou M, Saper CB, Faraco J, Sakurai T, Honda M, Mignot E, Scammell TE \"Concomitant loss of dynorphin, NARP, and orexin in narcolepsy.\" Neurology 2005

Chen W, Black J, Call P, Mignot E \"Late-onset narcolepsy presenting as rapidly progressing muscle weakness: Response to plasmapheresis.\" Ann Neurol 2005; 58: 3: 489-490

Mignot E, Nishino S \"Emerging therapies in narcolepsy-cataplexy.\" Sleep 2005; 28: 6: 754-63

Arnulf I, Zeitzer JM, File J, Farber N, Mignot E \"Kleine-Levin syndrome: a systematic review of 186 cases in the literature.\" Brain 2005

Mignot E, \"An update on the pharmacotherapy of excessive daytime sleepiness and cataplexy.\" Sleep Med Rev 2004; 8: 5: 333-8

Mignot E, \"Sleep, sleep disorders and hypocretin (orexin).\" Sleep Med 2004; 5 Suppl 1: S2-8

Zhang S, Zeitzer JM, Yoshida Y, Wisor JP, Nishino S, Edgar DM, Mignot E \"Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release.\" Sleep 2004; 27: 4: 619-27

Okura M, Fujiki N, Kita I, Honda K, Yoshida Y, Mignot E, Nishino S \"The roles of midbrain and diencephalic dopamine cell groups in the regulation of cataplexy in narcoleptic Dobermans.\" Neurobiol Dis 2004; 16: 1: 274-82

Zeitzer JM, Buckmaster CL, Lyons DM, Mignot E \"Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys.\" J Physiol 2004; 557: Pt 3: 1045-53

Mignot E, \"A year in review--basic science, narcolepsy, and sleep in neurologic diseases.\" Sleep 2004; 27: 6: 1209-12

Lin L, Finn L, Zhang J, Young T, Mignot E \"Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension.\" Am J Respir Crit Care Med 2004; 170: 12: 1349-53

Fromherz S, Mignot E \"Narcolepsy research: past, present, and future perspectives.\" Arch Ital Biol 2004; 142: 4: 479-86

Taheri S, Lin L, Austin D, Young T, Mignot E \"Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index.\" PLoS Med 2004; 1: 3: e62

Fujiki N, Yoshida Y, Ripley B, Mignot E, Nishino S \"Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog.\" Sleep 2003; 26: 8: 953-9

Zeitzer JM, Buckmaster CL, Parker KJ, Hauck CM, Lyons DM, Mignot E \"Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness.\" J Neurosci 2003; 23: 8: 3555-60

Hecht M, Lin L, Kushida CA, Umetsu DT, Taheri S, Einen M, Mignot E \"Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy.\" Sleep 2003; 26: 7: 809-10

Nishino S, Kanbayashi T, Fujiki N, Uchino M, Ripley B, Watanabe M, Lammers GJ, Ishiguro H, Shoji S, Nishida Y, Overeem S, Toyoshima I, Yoshida Y, Shimizu T, Taheri S, Mignot E \"CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies.\" Neurology 2003; 61: 6: 823-5

Nishino S, Mignot E \"Article reviewed: Plasma orexin-A is lower in patients with narcolepsy.\" Sleep Med 2002; 3: 4: 377-8

Taheri S, Mignot E \"The genetics of sleep disorders.\" Lancet Neurol 2002; 1: 4: 242-50

Mignot E, Taheri S, Nishino S \"Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders.\" Nat Neurosci 2002; 5 Suppl: 1071-5

Shiba T, Ozu M, Yoshida Y, Mignot E, Nishino S \"Hypocretin stimulates [(35)S]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate.\" Biochem Biophys Res Commun 2002; 294: 3: 615-20

Fujiki N, Morris L, Mignot E, Nishino S \"Analysis of onset location, laterality and propagation of cataplexy in canine narcolepsy.\" Psychiatry Clin Neurosci 2002; 56: 3: 275-6

Okun ML, Lin L, Pelin Z, Hong S, Mignot E \"Clinical aspects of narcolepsy-cataplexy across ethnic groups.\" Sleep 2002; 25: 1: 27-35

Nishino S, Ripley B, Mignot E, Benson KL, Zarcone VP \"CSF hypocretin-1 levels in schizophrenics and controls: relationship to sleep architecture.\" Psychiatry Res 2002; 110: 1: 1-7

Taheri S, Zeitzer JM, Mignot E \"The role of hypocretins (orexins) in sleep regulation and narcolepsy.\" Annu Rev Neurosci 2002; 25: 283-313

Mignot E, Lammers GJ, Ripley B, Okun M, Nevsimalova S, Overeem S, Vankova J, Black J, Harsh J, Bassetti C, Schrader H, Nishino S \"The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.\" Arch Neurol 2002; 59: 10: 1553-62

Lin L, Wisor J, Shiba T, Taheri S, Yanai K, Wurts S, Lin X, Vitaterna M, Takahashi J, Lovenberg TW, Koehl M, Uhl G, Nishino S, Mignot E \"Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background.\" Peptides 2002; 23: 12: 2203-11

Ripley B, Overeem S, Fujiki N, Nevsimalova S, Uchino M, Yesavage J, Di Monte D, Dohi K, Melberg A, Lammers GJ, Nishida Y, Roelandse FW, Hungs M, Mignot E, Nishino S \"CSF hypocretin/orexin levels in narcolepsy and other neurological conditions.\" Neurology 2001; 57: 12: 2253-8

Mignot E, \"A commentary on the neurobiology of the hypocretin/orexin system.\" Neuropsychopharmacology 2001; 25: 5 Suppl: S5-13

Nishino S, Ripley B, Overeem S, Nevsimalova S, Lammers GJ, Vankova J, Okun M, Rogers W, Brooks S, Mignot E \"Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy.\" Ann Neurol 2001; 50: 3: 381-8

Lin L, Hungs M, Mignot E \"Narcolepsy and the HLA region.\" J Neuroimmunol 2001; 117: 1-2: 9-20

Kadotani H, Kadotani T, Young T, Peppard PE, Finn L, Colrain IM, Murphy GM, Mignot E \"Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults.\" JAMA 2001; 285: 22: 2888-90

Li R, Faraco JH, Lin L, Lin X, Hinton L, Rogers W, Lowe JK, Ostrander EA, Mignot E \"Physical and radiation hybrid mapping of canine chromosome 12, in a region corresponding to human chromosome 6p12-q12.\" Genomics 2001; 73: 3: 299-315

Mignot E, Lin L, Rogers W, Honda Y, Qiu X, Lin X, Okun M, Hohjoh H, Miki T, Hsu S, Leffell M, Grumet F, Fernandez-Vina M, Honda M, Risch N \"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.\" Am J Hum Genet 2001; 68: 3: 686-99

Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM \"Dopaminergic role in stimulant-induced wakefulness.\" J Neurosci 2001; 21: 5: 1787-94

Hungs M, Fan J, Lin L, Lin X, Maki RA, Mignot E \"Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines.\" Genome Res 2001; 11: 4: 531-9

Fujiki N, Yoshida Y, Ripley B, Honda K, Mignot E, Nishino S \"Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation.\" Neuroreport 2001; 12: 5: 993-7

Mignot E, \"A hundred years of narcolepsy research.\" Arch Ital Biol 2001; 139: 3: 207-20

Hungs M, Mignot E \"Hypocretin/orexin, sleep and narcolepsy.\" Bioessays 2001; 23: 5: 397-408

Okura M, Fujiki N, Ripley B, Takahashi S, Amitai N, Mignot E, Nishino S \"Narcoleptic canines display periodic leg movements during sleep.\" Psychiatry Clin Neurosci 2001; 55: 3: 243-4

Ripley B, Fujiki N, Okura M, Mignot E, Nishino S \"Hypocretin levels in sporadic and familial cases of canine narcolepsy.\" Neurobiol Dis 2001; 8: 3: 525-34

Nishino S, Fujiki N, Ripley B, Sakurai E, Kato M, Watanabe T, Mignot E, Yanai K \"Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs.\" Neurosci Lett 2001; 313: 3: 125-8

Yoshida Y, Fujiki N, Nakajima T, Ripley B, Matsumura H, Yoneda H, Mignot E, Nishino S \"Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities.\" Eur J Neurosci 2001; 14: 7: 1075-81

Hungs M, Lin L, Okun M, Mignot E \"Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy.\" Neurology 2001; 57: 10: 1893-5

Nishino S, Okura M, Mignot E \"Narcolepsy: genetic predisposition and neuropharmacological mechanisms. REVIEW ARTICLE.\" Sleep Med Rev 2000; 4: 1: 57-99

Pedrazzoli M, Ling L, Finn L, Kubin L, Young T, Katzenberg D, Mignot E \"A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults.\" Sleep Res Online 2000; 3: 2: 73-6

Nishino S, Riehl J, Hong J, Kwan M, Reid M, Mignot E \"Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans.\" Neurosci Res 2000; 38: 4: 437-46

Okura M, Riehl J, Mignot E, Nishino S \"Sulpiride, a D2/D3 blocker, reduces cataplexy but not REM sleep in canine narcolepsy.\" Neuropsychopharmacology 2000; 23: 5: 528-38

Kanbayashi T, Honda K, Kodama T, Mignot E, Nishino S \"Implication of dopaminergic mechanisms in the wake-promoting effects of amphetamine: a study of D- and L-derivatives in canine narcolepsy.\" Neuroscience 2000; 99: 4: 651-9

Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E \"Hypocretin (orexin) deficiency in human narcolepsy.\" Lancet 2000; 355: 9197: 39-40

Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E \"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.\" Nat Med 2000; 6: 9: 991-7

Riehl J, Honda K, Kwan M, Hong J, Mignot E, Nishino S \"Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy.\" Neuropsychopharmacology 2000; 23: 1: 34-45

Mignot E, \"Perspectives in narcolepsy and hypocretin (orexin) research.\" 2000; 1: 2: 87-90

Riehl J, Okura M, Mignot E, Nishino S \"Inheritance of von Willebrand\'s disease in a colony of Doberman Pinschers.\" Am J Vet Res 2000; 61: 2: 115-20

Faraco J, Lin X, Li R, Hinton L, Lin L, Mignot E \"Genetic studies in narcolepsy, a disorder affecting REM sleep.\" J Hered 1999 Jan-Feb; 90: 1: 129-32

Honda K, Riehl J, Mignot E, Nishino S \"Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep.\" Neuroreport 1999; 10: 17: 3717-24

Nishino S, Mignot E \"Drug treatment of patients with insomnia and excessive daytime sleepiness: pharmacokinetic considerations.\" Clin Pharmacokinet 1999; 37: 4: 305-30

Honda K, Riehl J, Mignot E, Nishino S \"Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep [corrected]\" Neuroreport 1999; 10: 14: 3111-8

Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E \"The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.\" Cell 1999; 98: 3: 365-76

Katzenberg D, Young T, Lin L, Finn L, Mignot E \"A human period gene (HPER1) polymorphism is not associated with diurnal preference in normal adults.\" Psychiatr Genet 1999; 9: 2: 107-9

Mignot E, Young T, Lin L, Finn L \"Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602.\" Sleep 1999; 22: 3: 347-52

Li R, Mignot E, Faraco J, Kadotani H, Cantanese J, Zhao B, Lin X, Hinton L, Ostrander EA, Patterson DF, de Jong PJ \"Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library.\" Genomics 1999; 58: 1: 9-17

Anic-Labat S, Guilleminault C, Kraemer HC, Meehan J, Arrigoni J, Mignot E \"Validation of a cataplexy questionnaire in 983 sleep-disorders patients.\" Sleep 1999; 22: 1: 77-87

Nishino S, Honda K, Riehl J, Okura M, Mignot E \"Neuronal activity in the cholinoceptive basal forebrain of freely moving narcoleptic dobermans.\" Neuroreport 1998; 9: 16: 3653-61

Katzenberg D, Young T, Finn L, Lin L, King DP, Takahashi JS, Mignot E \"A CLOCK polymorphism associated with human diurnal preference.\" Sleep 1998; 21: 6: 569-76

Lin L, Jin L, Lin X, Voros A, Underhill P, Mignot E \"Microsatellite single nucleotide polymorphisms in the HLA-DQ region.\" Tissue Antigens 1998; 52: 1: 9-18

Riehl J, Nishino S, Cederberg R, Dement WC, Mignot E \"Development of cataplexy in genetically narcoleptic Dobermans.\" Exp Neurol 1998; 152: 2: 292-302

Nishino S, Mignot E, Benson KL, Zarcone VP \"Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture.\" Psychiatry Res 1998; 78: 3: 141-50

Reid MS, Nishino S, Tafti M, Siegel JM, Dement WC, Mignot E \"Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines.\" Exp Neurol 1998; 151: 1: 89-104

Kadotani H, Faraco J, Mignot E \"Genetic studies in the sleep disorder narcolepsy.\" Genome Res 1998; 8: 5: 427-34

Mignot E, \"Genetic and familial aspects of narcolepsy.\" Neurology 1998; 50: 2 Suppl 1: S16-22

Guilleminault C, Heinzer R, Mignot E, Black J \"Investigations into the neurologic basis of narcolepsy.\" Neurology 1998; 50: 2 Suppl 1: S8-15

Cederberg R, Nishino S, Dement WC, Mignot E \"Breeding history of the Stanford colony of narcoleptic dogs.\" Vet Rec 1998; 142: 2: 31-6

Honda K, Riehl J, Inoué S, Mignot E, Nishino S \"Central administration of vitamin B12 aggravates cataplexy in canine narcolepsy.\" Neuroreport 1997; 8: 18: 3861-5

Mignot E, Hayduk R, Black J, Grumet FC, Guilleminault C \"HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients.\" Sleep 1997; 20: 11: 1012-20

Lin L, Jin L, Kimura A, Carrington M, Mignot E \"DQ microsatellite association studies in three ethnic groups.\" Tissue Antigens 1997; 50: 5: 507-20

Nishino S, Arrigoni J, Shelton J, Kanbayashi T, Dement WC, Mignot E \"Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy.\" J Neurosci 1997; 17: 16: 6401-8

Nishino S, Tafti M, Sampathkumaran R, Dement WC, Mignot E \"Circadian distribution of rest/activity in narcoleptic and control dogs: assessment with ambulatory activity monitoring.\" J Sleep Res 1997; 6: 2: 120-7

Mignot E, \"Genetics of narcolepsy and other sleep disorders.\" Am J Hum Genet 1997; 60: 6: 1289-302

Nishino S, Mignot E \"Pharmacological aspects of human and canine narcolepsy.\" Prog Neurobiol 1997; 52: 1: 27-78

Mignot E, Kimura A, Lattermann A, Lin X, Yasunaga S, Mueller-Eckhardt G, Rattazzi C, Lin L, Guilleminault C, Grumet FC, Mayer G, Dement WC, Underhill P \"Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy.\" Tissue Antigens 1997; 49: 4: 329-41

Tafti M, Nishino S, Liao W, Dement WC, Mignot E \"Mesopontine organization of cholinergic and catecholaminergic cell groups in the normal and narcoleptic dog.\" J Comp Neurol 1997; 379: 2: 185-97

Jin L, Macaubas C, Hallmayer J, Kimura A, Mignot E \"Mutation rate varies among alleles at a microsatellite locus: phylogenetic evidence.\" Proc Natl Acad Sci U S A 1996; 93: 26: 15285-8

Kanbayashi T, Nishino S, Tafti M, Hishikawa Y, Dement WC, Mignot E \"Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.\" Neuroreport 1996; 7: 12: 1881-6

Tafti M, Nishino S, Aldrich MS, Liao W, Dement WC, Mignot E \"Major histocompatibility class II molecules in the CNS: increased microglial expression at the onset of narcolepsy in canine model.\" J Neurosci 1996; 16: 15: 4588-95

Kanbayashi T, Nishino S, Tafti M, Hishikawa Y, Dement WC, Mignot E \"Thalidomide, immune modulation and narcolepsy.\" Sleep 1996; 19: 2: 116

Shelton J, Nishino S, Vaught J, Dement WC, Mignot E \"Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs.\" Sleep 1995; 18: 10: 817-26

Mignot E, Kimura A, Abbal M, Thorsby E, Lin X, Voros A, Macaubas C, Bouissou F, Sollid LM, Cambon-Thomsen A \"DQCAR microsatellite polymorphisms in three selected HLA class II-associated diseases.\" Tissue Antigens 1995; 46: 4: 299-304

Nishino S, Tafti M, Reid MS, Shelton J, Siegel JM, Dement WC, Mignot E \"Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy.\" J Neurosci 1995; 15: 7 Pt 1: 4806-14

Nishino S, Shelton J, Renaud A, Dement WC, Mignot E \"Effect of 5-HT1A receptor agonists and antagonists on canine cataplexy.\" J Pharmacol Exp Ther 1995; 272: 3: 1170-5

Mignot E, Tafti M, Dement WC, Grumet FC \"Narcolepsy and immunity.\" Adv Neuroimmunol 1995; 5: 1: 23-37

Behar E, Lin X, Grumet FC, Mignot E \"A new DRB1*1202 allele (DRB1*12022) found in association with DQA1*0102 and DQB1*0602 in two black narcoleptic subjects.\" Immunogenetics 1995; 41: 1: 52

Nishino S, Reid MS, Dement WC, Mignot E \"Neuropharmacology and neurochemistry of canine narcolepsy.\" Sleep 1994; 17: 8 Suppl: S84-92

Mignot E, Bell RA, Rattazzi C, Lovett M, Grumet FC, Dement WC \"An immunoglobulin switchlike sequence is linked with canine narcolepsy.\" Sleep 1994; 17: 8 Suppl: S68-76

Mignot E, Lin X, Arrigoni J, Macaubas C, Olive F, Hallmayer J, Underhill P, Guilleminault C, Dement WC, Grumet FC \"DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans.\" Sleep 1994; 17: 8 Suppl: S60-7

Guilleminault C, Mignot E, Partinen M \"Controversies in the diagnosis of narcolepsy.\" Sleep 1994; 17: 8 Suppl: S1-6

Mignot E, Nishino S, Guilleminault C, Dement WC \"Modafinil binds to the dopamine uptake carrier site with low affinity.\" Sleep 1994; 17: 5: 436-7

Reid MS, Tafti M, Nishino S, Siegel JM, Dement WC, Mignot E \"Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors.\" Sleep 1994; 17: 5: 424-35

Reid MS, Siegel JM, Dement WC, Mignot E \"Cholinergic mechanisms in canine narcolepsy--II. Acetylcholine release in the pontine reticular formation is enhanced during cataplexy.\" Neuroscience 1994; 59: 3: 523-30

Reid MS, Tafti M, Geary JN, Nishino S, Siegel JM, Dement WC, Mignot E \"Cholinergic mechanisms in canine narcolepsy--I. Modulation of cataplexy via local drug administration into the pontine reticular formation.\" Neuroscience 1994; 59: 3: 511-22

Gelb M, Guilleminault C, Kraemer H, Lin S, Moon S, Dement WC, Mignot E \"Stability of cataplexy over several months--information for the design of therapeutic trials.\" Sleep 1994; 17: 3: 265-73

Nishino S, Arrigoni J, Shelton J, Dement WC, Mignot E \"Desmethyl metabolites of serotonergic uptake inhibitors are more potent for suppressing canine cataplexy than their parent compounds.\" Sleep 1993; 16: 8: 706-12

Nishino S, Fruhstorfer B, Arrigoni J, Guilleminault C, Dement WC, Mignot E \"Further characterization of the alpha-1 receptor subtype involved in the control of cataplexy in canine narcolepsy.\" J Pharmacol Exp Ther 1993; 264: 3: 1079-84

Mignot E, Nishino S, Sharp LH, Arrigoni J, Siegel JM, Reid MS, Edgar DM, Ciaranello RD, Dement WC \"Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.\" J Neurosci 1993; 13: 3: 1057-64

Mignot E, Renaud A, Nishino S, Arrigoni J, Guilleminault C, Dement WC \"Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers.\" Psychopharmacology (Berl) 1993; 113: 1: 76-82

Mignot E, Lin X, Kalil J, George C, Singh S, Billiard M, Montplaisir J, Arrigoni J, Guilleminault C, Dement WC \"DQB1-0602 (DQw1) is not present in most nonDR2 Caucasian narcoleptics.\" Sleep 1992; 15: 5: 415-22

Valtier D, Dement WC, Mignot E \"Monoaminergic uptake in synaptosomes prepared from frozen brain tissue samples of normal and narcoleptic canines.\" Brain Res 1992; 588: 1: 115-9

Renaud A, Nishino S, Dement WC, Guilleminault C, Mignot E \"Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep.\" Eur J Pharmacol 1991; 205: 1: 11-6

Haak LL, Mignot E, Kilduff TS, Dement WC, Heller HC \"Regional changes in central monoamine and metabolite levels during the hibernation cycle in the golden-mantled ground squirrel.\" Brain Res 1991; 563: 1-2: 215-20

Nishino S, Arrigoni J, Valtier D, Miller JD, Guilleminault C, Dement WC, Mignot E \"Dopamine D2 mechanisms in canine narcolepsy.\" J Neurosci 1991; 11: 9: 2666-71

Mignot E, Wang C, Rattazzi C, Gaiser C, Lovett M, Guilleminault C, Dement WC, Grumet FC \"Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment.\" Proc Natl Acad Sci U S A 1991; 88: 8: 3475-8

Valtier D, Nishino S, Guilleminault C, Dement WC, Mignot E \"Platelet alpha 2 adrenoceptors in human and canine narcolepsy.\" Biol Psychiatry 1991; 29: 4: 376-82

Nishino S, Mignot E, Kilduff TS, Sakai T, Hayaishi O, Dement WC \"Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs.\" Biol Psychiatry 1990; 28: 10: 904-10

Nishino S, Haak L, Shepherd H, Guilleminault C, Sakai T, Dement WC, Mignot E \"Effects of central alpha-2 adrenergic compounds on canine narcolepsy, a disorder of rapid eye movement sleep.\" J Pharmacol Exp Ther 1990; 253: 3: 1145-52

Guilleminault C, Mignot E, Grumet FC \"Familial patterns of narcolepsy.\" Lancet 1989; 2: 8676: 1376-9

Fruhstorfer B, Mignot E, Bowersox S, Nishino S, Dement WC, Guilleminault C \"Canine narcolepsy is associated with an elevated number of alpha 2-receptors in the locus coeruleus.\" Brain Res 1989; 500: 1-2: 209-14

Mignot E, Guilleminault C, Bowersox S, Frusthofer B, Nishino S, Maddaluno J, Ciaranello R, Dement WC \"Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.\" Brain Res 1989; 490: 1: 186-91

Mignot E, Bowersox SS, Maddaluno J, Dement W, Ciaranello R \"Evidence for multiple [3H]prazosin binding sites in canine brain membranes.\" Brain Res 1989; 486: 1: 56-66

Nishino S, Mignot E, Fruhstorfer B, Dement WC, Hayaishi O \"Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy.\" Proc Natl Acad Sci U S A 1989; 86: 7: 2483-7

Mignot E, Guilleminault C, Bowersox S, Rappaport A, Dement WC \"Role of central alpha-1 adrenoceptors in canine narcolepsy.\" J Clin Invest 1988; 82: 3: 885-94

Mignot E, Guilleminault C, Bowersox S, Rappaport A, Dement WC \"Effect of alpha 1-adrenoceptors blockade with prazosin in canine narcolepsy.\" Brain Res 1988; 444: 1: 184-8

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